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Allergic reactions to proprietary preparations of vitamin B12 might be due to substances added to the solutions as preservatives or for other reasons, to impurities from the production, or to the vitamin B12 itself

However, folic acid does not prevent neurological symptoms, and without proper treatment with vitamin B12, irreversible damage may occur

Topical uses percentages

Most side effects are mild and injection-related

Relative telomere length and mitochondrial DNA copy number variation with age: association with plasma folate and vitamin B12. Mitochondrion 51 (2020): 79-87.

It doesn't go in and obliterate any bacteria that might be present